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This is a Quantitative Study study.

September 17, 2025eLifeOpen Access

Regulating closure of the neural tube in humans

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The study identifies critical genes involved in neural tube closure, which is vital for proper embryonic development.
Using an organoid-based screening platform, the research allows for one-gene-at-a-time knockdown to pinpoint regulatory functions.
The findings enhance the understanding of developmental biology and the genetic basis of neural tube defects.
The innovative approach highlights how specific genes can be targeted for better insights into human tissue development.

Implication

An organoid-based platform reveals key genes involved in neural tube closure, suggesting potential regulatory mechanisms.

Abstract

An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.

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Cite This Study

Qarawani et al. (2025) studied this question.

synapsesocial.com/papers/68d45b3431b076d99fa5df93 https://doi.org/10.7554/elife.108870

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Implication

An organoid-based platform reveals key genes involved in neural tube closure, suggesting potential regulatory mechanisms.

Abstract

An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.

Regulating closure of the neural tube in humans

Key Points

Implication

Abstract

Discussion

Cite This Study

Regulating closure of the neural tube in humans

Key Points

Implication

Abstract

Discussion

Cite This Study

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