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September 17, 2025PharmaceuticsOpen Access

A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology

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Authors

PSPhilippe-Henri SecrétanUniversité Paris-SaclayMAMaxime AnnereauInsermBDBernard DoCentre National de la Recherche Scientifique

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Implication

This framework integrates degradation mechanisms with predictive toxicology in hospital compounding, suggesting improvements in safety and quality.

Key Points

  • The framework enhances the safety and quality of compounded preparations, crucial for patient-tailored therapies.
  • Integration of degradation profiling and toxicology evaluates critical quality attributes and process parameters.
  • Formulation strategies utilize a decision tree that aids solvent selection, pH adjustment, and excipient compatibility.
  • Empirical practices in hospital compounding are transformed through structured guidance on stability and impurity control.

Cite This Study

Secrétan et al. (2025) studied this question.

synapsesocial.com/papers/68d45b3431b076d99fa5dfb5https://doi.org/10.3390/pharmaceutics17091202
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