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September 17, 2025BiomoleculesOpen Access

EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage

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Authors

AMAbhishek MishraMBMarcus de BourgRMRawand S. Mohamed

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Overview

Experimental analysis shows that 8,9-EET analogs improve cell viability in glomerular cells, indicating their potential against nephrotoxicity.

Key Points

  • 8,9-EET analogs significantly enhanced cell survival and decreased apoptosis in human renal mesangial cells.
  • Treatment with 1–10 µM sorafenib reduced cell viability and increased caspase 3/7 activity in both HRMCs and podocytes.
  • RNA sequencing revealed that sorafenib altered 1244 genes, impacting key pathways related to glomerular health.
  • MDB-52a increased ANGPTL4 levels and reduced ACTA2, suggesting activation of protective pathways against nephrotoxicity.

Cite This Study

Mishra et al. (2025) studied this question.

synapsesocial.com/papers/68d45e4431b076d99fa5e001https://doi.org/10.3390/biom15091324
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