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September 17, 2025Arthritis & RheumatologyOpen Access

Performance of an Idiopathic Pulmonary Fibrosis Derived Multibiomarker Panel for Rheumatoid Arthritis‐Associated Interstitial Lung Disease

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Observational analysis identifies IPF-derived biomarker scores predicting ILD risk in RA patients, suggesting new diagnostic insights.

Participants in the highest quartile of multibiomarker scores had over twice the odds of prevalent ILD compared to the lowest quartile.
The cumulative hazard for incident ILD reached nearly 20% over 15 years for participants in the highest quartile of biomarker scores.
This multibiomarker panel derived from IPF biomarkers was associated with ILD in rheumatoid arthritis across multiple cohorts.
The findings indicate a shared etiopathogenesis between idiopathic pulmonary fibrosis and rheumatoid arthritis-associated interstitial lung disease.

Luedders et al. (2025) studied this question.

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