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October 1, 2025Open Access

Risk Factors Associated with Interstitial Lung Disease in Rheumatoid Arthritis: A Monocentric Clinical and Serological Assessment

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Authors

NLNing LiuYZYongfeng ZhangGWGang Wang

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Overview

Analysis identifies risk factors and develops a predictive model for interstitial lung disease in rheumatoid arthritis patients, highlighting key biomarkers.

Key Points

  • Risk factors include male gender, smoking, and elevated biomarkers, with significant associations found.
  • Optimal biomarker thresholds were established: rheumatoid factor > 352.5 IU/mL and anti-CCP antibodies > 43.25 IU/mL.
  • Multivariate analysis confirmed C3, TNF-α, and biologic therapy as independent predictors for interstitial lung disease.
  • The nomogram demonstrated strong discrimination with a C-index of 0.829, facilitating early risk stratification.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68dd89d7fe798ba2fc497afdhttps://doi.org/10.21203/rs.3.rs-7500736/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors associated with interstitial lung disease in patients with rheumatoid arthritis2024
  2. 2Identifying clinical features and biomarkers associated with interstitial lung disease in rheumatoid arthritis patients2026
  3. 3Development and validation of a risk prediction model for interstitial lung disease in patients with rheumatoid arthritis2026
  4. 4AB0180 FROM SYNOVIUM TO ALVEOLI: INTERROGATING DIFFUSE INTERSTITIAL PNEUMONIA IN RHEUMATOID ARTHRITIS AND ITS SYNERGY WITH ANTI-CCP ANTIBODIES2024
  5. 5The prevalence and factors associated with rheumatoid arthritis-associated interstitial lung disease2024