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September 17, 2025Journal of FungiOpen Access

Properties of Putative APSES Transcription Factor AfpA in Aspergillus fumigatus

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Authors

YCYoung‐Ho ChoiMLMin-Woo LeeKSKwang-Soo Shin

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Overview

Study finds AfpA regulates growth and virulence in Aspergillus fumigatus, indicating its crucial role in pathogenic fungi.

Key Points

  • The ΔafpA mutant showed reduced vegetative growth and increased conidiation due to altered gene regulation.
  • Key regulators of asexual development, brlA, abaA, and wetA, were upregulated in the ΔafpA mutant, suggesting AfpA's regulatory role.
  • AfpA positively influences cAMP-PKA signaling, affecting conidia germination timing significantly.
  • Enhanced virulence was observed in neutropenic mice infected with the ΔafpA mutant, highlighting AfpA's impact on pathogenicity.

Cite This Study

Choi et al. (2025) studied this question.

synapsesocial.com/papers/68d45e4431b076d99fa5e105https://doi.org/10.3390/jof11090678
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on the biological role of the antifungal protein PeAfpA from Penicillium expansum by functional gene characterization and transcriptomic profiling2024 · 5 citations
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  3. 3FphA Positively Regulates Fungal Development and AFB<sub>1</sub> Biosynthesis and Phosphorylates Ypd1 in <i>Aspergillus flavus</i>2025 · 1 citations
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  5. 5Distinct roles of phytochromes A and B in <i>Aspergillus fumigatus</i> in environmental sensing and pathogenicity2025