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Genes Encoding Heat Shock Proteins Are Associated with Risk and Clinical Course of Severe COVID-19: A Pilot Study

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Pilot study shows genetic variants in HSPs impact severe COVID-19 risk in hospitalized patients, suggesting connections to inflammation.

SNP rs7189628 in DNAJA2 significantly increases the risk of severe COVID-19 across various groups.
SNP rs910652 in HSPA12B decreases the severe COVID-19 risk in females and those with normal physical activity levels.
Genetic variants in heat shock proteins were found to influence blood coagulation and inflammation in COVID-19 patients.
This pilot study highlights the potential role of genetic factors in predicting severe outcomes from COVID-19.

Karpenko et al. (2025) studied this question.

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