Isolation and characterization of ulleungpeptins reveal antiangiogenic properties in cells, suggesting potential therapeutic applications.
Two new lipopeptides, ulleungpeptins A and B (1 and 2), were isolated from cultures of Streptomyces sp. 13F051. Spectroscopic analyses revealed that both compounds consist of a 2,4-decadienoic acid moiety conjugated to a hexapeptide incorporating the non-proteinogenic amino acid 3,5-dihydroxyphenylglycines (Dpgs). Detailed NMR studies established that the two compounds differ in the configuration of the double bonds within the 2,4-decadienoic acid moiety. The absolute configurations of the amino acid residues were determined by advanced Marfey's analysis, supported by bioinformatic predictions. Bioactivity evaluation demonstrated that compounds 1 and 2 inhibit angiogenesis in HUVEC cells without exhibiting cytotoxicity.
No takes yet. Share an insight, caveat, or question.
Hwang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
More from Journal of Natural Products