Analysis reveals lipopeptides inhibit uric acid production in AML12 cells, suggesting therapeutic potential.
Two linear lipopeptides mabuniamide B (1) and C (2) were isolated from an Okeania sp. marine cyanobacterium collected from the coast of Okinawa. Their structures were elucidated by spectroscopic analyses, and their absolute configurations of amino acid residues were determined using Marfey's analysis of the hydrolysates of 1 and 2. In addition, 1 and 2 inhibited uric acid production in cultured AML12 cells.
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Higa et al. (2025) studied this question.
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