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September 17, 2025British Journal of Pharmacology

Beyond TGFβ inhibition: Chitosan oligosaccharide targets PGC‐1α‐mediated mitochondrial repair to combat pulmonary fibrosis

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Authors

HHHuan HeYXYoutao XuXCXinru Chen

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Overview

Observational analysis revealed chitosan oligosaccharides reduce pulmonary fibrosis severity in mice, indicating PGC-1α may enhance mitochondrial function.

Key Points

  • Chitosan oligosaccharides significantly alleviate pulmonary fibrosis symptoms compared to pirfenidone.
  • They inhibit AEC-I apoptosis and AEC-II epithelial-mesenchymal transition, reducing collagen deposition.
  • The therapeutic effect of chitosan oligosaccharides is mediated through the PGC-1α/PINK1/NRF1 pathway.
  • This intervention approach may redefine strategies for treating upstream epithelial injury in pulmonary fibrosis.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68d45e4e31b076d99fa5e74ahttps://doi.org/10.1111/bph.70190
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