The Prevalence and Risk Factors of Hyperuricemia in Chinese Children and Adolescents: A Meta-Analysis

Objective: To explore the prevalence and risk factors of hyperuricemia in Chinese children and adolescents by meta-analysis.Material and Methods: The China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service platform, VIP Periodical Chinese Journal Service platform, PubMed, Embase database, Chinese BioMedical Literature database (CBM), Cochrane Library, Web of Science, and a manual search were all included in the extensive search, which had a final search date of September 2024. The meta-analysis was conducted using RevMan 5.4 and Stata 17.0.Results: A total of 14 pieces of literature comprising 89359 patients were included. According to our review, the common risk factors reported were gender (male), age, overweight or obesity, hypertension, impaired glucose regulation, dyslipidemia, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and urea nitrogen were the key risk factors for hyperuricemia (HUA) in Chinese children and adolescents (p-value<0.05). In contrast, HUA in children and adolescents was not linked to a diet high in animal offal, waist circumference, or town residence (p-value>0.05).Conclusion: The high rate of hyperuricemia in Chinese children and adolescents serves as a reminder to the general public, medical professionals, and those who determine health policy to get ready for the challenges that lie ahead.