Figure 6 from Response to Antiangiogenic Therapy Is Associated with AIMP Protein Family Expression in Glioblastoma and Lower-Grade Gliomas

Spatial and cell type–specific expression of AIMP2 in GBM tumors. A, Spatial distribution of AIMP2 expression across tumor tissues in two representative GBM slides (i: slide 334_T and ii: slide 268_T) analyzed using a spatial transcriptomic dataset. The heatmaps display homogeneous expression of AIMP2 with varying intensity from low (purple) to high (yellow), indicating the absence of localized expression hotspots. B, Violin plots representing AIMP2 expression across GBM cellular subtypes. i,AIMP2 expression in key GBM subtypes, including MES-like, AC-like, oligodendrocyte progenitor cell (OPC)–like, and neural progenitor cell (NPC)–like cells from a concatenated single-cell RNA-seq cohort (Kruskal–Wallis P = 2.32e−02). ii,AIMP2 expression across malignant GBM subtypes from a spatial transcriptomic dataset. (Kruskal–Wallis P = 1.32e−03).