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This is a Literature Review study.

September 17, 2025Frontiers in MedicineOpen Access

The use of Eculizumab and Tocilizumab in the treatment of Hyperhemolysis syndrome, a comprehensive literature review

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Literature review reveals usage of eculizumab and tocilizumab in hyperhemolysis syndrome, suggesting efficacy in specific cases.

Improvement was observed in 18 patients treated with eculizumab or tocilizumab, indicating their potential benefit.
The review analyzed 22 cases of hyperhemolysis syndrome, where 11 received eculizumab and 10 received tocilizumab.
Most patients in the cohort had underlying hemoglobinopathies, highlighting the association with hyperhemolysis syndrome.
Further studies are needed to assess the safety and effectiveness of eculizumab and tocilizumab for hyperhemolysis syndrome.

Aqel et al. (2025) studied this question.

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