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September 17, 2025Journal of Drug Delivery and TherapeuticsOpen Access

Cannabis Compounds: Docking and Dynamics Study

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Authors

FBFatiha BousselhamMMMohammed MouhcineIGIkram Ghicha

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Overview

In silico analysis reveals high affinity of CBG for CB2 receptors, suggesting potential therapeutic applications.

Key Points

  • CBG shows the highest affinity for CB2 receptors at -7.9008 kcal/mol, indicating strong potential therapeutic effects.
  • The molecular docking and dynamics study utilized MOE and GROMACS to evaluate cannabis compounds' interactions with receptors.
  • The CB2-CBG complex exhibited high stability over 8000 ps, with an RMSD of 0.6993 Å, underscoring its promise as a therapeutic agent.
  • CBD also demonstrated significant binding with CB1 receptors, having an affinity of -7.4857 kcal/mol.

Cite This Study

Bousselham et al. (2025) studied this question.

synapsesocial.com/papers/68d45e6231b076d99fa5ee85https://doi.org/10.22270/jddt.v15i9.7371
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