October 16, 2025ProcessesOpen Access

Targeting GPR55 with Cannabidiol Derivatives: A Molecular Docking Approach Toward Novel Neurotherapeutics

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Bioinformatics analysis reveals CBD derivatives may effectively bind to GPR55 in CNS conditions, suggesting therapeutic potential.

Strong binding affinities of CBD derivatives to GPR55 suggest promising therapeutic applications in CNS.
Molecular docking scores between −9.2 and −7.2 kcal/mol demonstrate thermodynamically favorable interactions.
Key residues in GPR55's binding pocket indicate a structurally defined site for cannabinoid interaction.
Moderate oral bioavailability (0.55) implies potential for enhanced drug formulations targeting GPR55.

Mareş et al. (2025) studied this question.

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October 16, 2025ProcessesOpen Access

View Full Paper

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Authors

Bioinformatics analysis reveals CBD derivatives may effectively bind to GPR55 in CNS conditions, suggesting therapeutic potential.

Strong binding affinities of CBD derivatives to GPR55 suggest promising therapeutic applications in CNS.
Molecular docking scores between −9.2 and −7.2 kcal/mol demonstrate thermodynamically favorable interactions.
Key residues in GPR55's binding pocket indicate a structurally defined site for cannabinoid interaction.
Moderate oral bioavailability (0.55) implies potential for enhanced drug formulations targeting GPR55.

Mareş et al. (2025) studied this question.

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