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September 17, 2025Open Access

RNA-tailor: accurate gene-level identification of transcript isoform diversity from long reads

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RNA-tailor achieves high accuracy in identifying alternative splicing isoforms for single genes, enhancing precision.
Utilizing a combination of exact alignment algorithms and context-aware corrections, RNA-tailor offers significant improvements.
The tool shows higher sensitivity compared to conventional methods when analyzing isoform diversity from long reads.
Analysis of real and simulated datasets demonstrates RNA-tailor's superior performance in splicing isoform identification.

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RNA-tailor improves splicing isoform accuracy in transcript analysis, indicating advancements in gene-level identification.

Marchand et al. (2025) studied this question.

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