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September 17, 20250 citationsOpen Access

Mechanistic Insights into Shixiang Plaster for DFUs Healing via Network Pharmacology and Animal Study

Mechanistic Study of Shixiang Plaster in DFUs Treatment: Network Pharmacology, Animal Experimentation, and LC-MS Analysis

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Authors

PLPeng LiuYLYang LiuFJFei Ji

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Overview

This research reveals shixiang plaster's effects on dfus healing in animal models, suggesting mechanisms via network pharmacology and molecular docking.

Key Points

  • Shixiang plaster significantly enhances wound healing and reduces inflammation in dfus models.
  • The study identifies key active ingredients and therapeutic targets such as ESR1, RHOA, and BCL2.
  • Network pharmacology and in vivo analyses reveal pathways involved in apoptosis and angiogenesis.
  • Molecular docking confirms strong interactions between bioactive compounds and identified targets.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d4604031b076d99fa5f332https://doi.org/10.21203/rs.3.rs-6652265/v1
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