Randomized trial demonstrates improved wound healing in mice using combined herbal treatments, suggesting a novel therapeutic strategy.
Key Points
This study aims to evaluate the effects of Lingzhi Huang capsules and Zeng Jian Health Tonic on skin wound healing and elucidate underlying molecular mechanisms.
Characterization of LZH and ZJ using LC-MS/MS.
Full-thickness skin wound model in mice assessed through histopathological analysis and immunofluorescence.
In vitro analysis of HUVECs for angiogenesis, inflammation, and oxidative stress.
LZH and ZJ significantly accelerated wound closure and enhanced collagen deposition, with combined treatment showing pronounced effects.
Combined treatment increased cell proliferation and reduced ROS levels, alongside upregulation of GPX4, SLC7A11, and FTH1.
BMP5 was identified as a central regulatory target, with its overexpression replicating the anti-ferroptotic effects.