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May 9, 2026Current Pharmaceutical Design0 citations

Yinzhilan Formula Enhances Healing of Diabetic Ulcers by Targeting PARP1 and Macrophage Polarization

Yinzhilan Formula Ameliorates Healing Delay in Diabetic Ulcer by Inhibiting PARP1 Activation and Regulating Macrophage Polarization

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Authors

JFJiawei FengYNYiming NiWZWei Zhang

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Overview

Randomized trial shows that Yinzhilan formula improves healing in diabetic ulcers, suggesting new therapeutic pathways.

Key Points

  • This study evaluates how Yinzhilan formula impacts the healing process of diabetic ulcers by modifying macrophage behavior and inhibiting specific molecular pathways.
  • Network pharmacology analyzed the components and targets of Yinzhilan formula.
  • A diabetic ulcer mouse model was created to test the effects of Yinzhilan formula on wound healing.
  • Histopathological assessments, cytokine detection via ELISA, and flow cytometry were used to evaluate treatment outcomes.
  • Yinzhilan formula significantly promoted wound healing by enhancing closure rates and reducing ulcer size.
  • PARP1 and STAT3 expression levels were decreased, with evidence indicating macrophage polarization shifted towards the M2 phenotype.
  • 291 potential targets were identified, showing a synergistic effect on healing mechanisms through inflammatory regulation.

Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69fed090b9154b0b82877960https://doi.org/10.2174/0113816128437855260214193425
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