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Synapse
September 17, 2025Advanced medical journalOpen Access

Combination of 20% Azelaic Acid Cream and 20% Salicylic Acid Peel Versus Azelaic Acid Cream Alone in the Treatment of Melasma Patients

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Authors

SRShadiya Abdullah RasolAEAli Mozan Dhahir Elethawi

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Overview

Comparative clinical trial shows combination therapy reduces melasma severity more than azelaic acid alone.

Key Points

  • Combination therapy with azelaic acid and salicylic acid significantly reduces melasma severity scores compared to azelaic acid alone.
  • In a clinical trial with 40 patients, group A experienced a notable decrease in melasma scores from 7.70 to 4.47.
  • The trial involved evaluations every two weeks, utilizing photographic assessments and scoring methods for monitoring.
  • Findings indicate that combined treatment leads to improved results while minimizing side effects compared to monotherapy.

Cite This Study

Rasol et al. (2025) studied this question.

synapsesocial.com/papers/68d4604031b076d99fa5f510https://doi.org/10.56056/amj.2025.386
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