Serum Visfatin Level Among Patients with Subclinical Hypothyroidism in Relation to Insulin Resistance

Background and Objectives: Subclinical hypothyroidism is a disorganization of the thyroid gland determined by normal free T4 and T3 with elevated thyroid stimulating hormone. The patients with subclinical hypothyroidism are asymptomatic, it can only be diagnosed through laboratory tests. The prevalence of subclinical hypothyroidism ranged from (4.6 to 16.7%) worldwide. The current study intended to evaluate the level of serum visfatin among patients with subclinical hypothyroidism and it is relation to insulin resistance in opposition to in good health control. Methods: This study was performed as a cross-sectional study on January 2023 among 160 participants, 80 newly diagnosed subclinical hypothyroidism and 80 healthy personnel as control group. Subclinical hypothyroid individuals were recruited from patients attending Diabetes and Endocrinology Unit in Azadi Teaching Hospital, 80 healthy personnel were picked from relatives and neighbors. Blood samples were collected from both groups for serum (TSH, T4, T3, sugar, insulin, visfatin). Comparison of results were compared. Results: There was no notable distinction between mean serum visfatin level in subclinical hypothyroidism patients (39.78±11.64) and controls (39.82±10.02).No notable differences were detected in the mean between subclinical hypothyroidism patients with TSH less than (10 microIU/ml) and those with TSH more than (10 microIU/ml) as follows:(p =0.869), insulin(p=0.214), FBS (p=0.811), and HOMA-IR (p=0.511).The mean of visfatin patients with normal HOMA-IR was (37.89) , compared with 40.29 of patients with high HOMA-IR, but the distinction was not of particular note (p=0.454). Conclusion: There was no particularly notable change of mean serum visfatin level in Subclinical hypothyroid patients, contrary to healthy individuals.