This research explains the reshaping of NADH oxidase, facilitating regeneration of NCD+ in redox pathways, suggesting a novel approach for chiral synthesis.
Oxidative and reductive reactions are vital processes in cellular metabolism. Like yin and yang in Tai Chi, they are independent and complementary. The non-natural cofactors NCD+ and NCDH exhibit substantial potential for the bio-orthogonal regulation of redox pathways. To provide sufficient driving force, it is crucial to maintain the NCD+ and NCDH ratio and homeostasis. In the Research Article 10.1002/cbic.202500254, Xueying Wang, Zongbao K. Zhao, and co-workers explain how they reshaped the NADH-binding pocket of NADH oxidase to accommodate NCDH, thereby facilitating the traceless regeneration of the oxidized cofactor NCD+ and the selective synthesis of chiral compounds.
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Wang et al. (2025) studied this question.
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