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September 17, 2025Frontiers in ImmunologyOpen Access

Commentary: Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy

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Authors

CICristiana IndolfiAKAngela KlainGDGiulio Dinardo

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Overview

Observational study reveals long COVID affects 16% of children, suggesting neuropsychological and respiratory follow-up is essential.

Key Points

  • Approximately 16% of infected children report long COVID symptoms lasting over two months, impacting their quality of life.
  • The study followed over 1,100 participants across 12 Italian centers, documenting persistent symptoms and their effects.
  • Observational, prospective, longitudinal study utilized standardized outcomes, including lung ultrasound and psychological assessments.
  • The findings underscore the need for comprehensive care strategies that address both physical and emotional aspects of long COVID.

Cite This Study

Indolfi et al. (2025) studied this question.

synapsesocial.com/papers/68d4605131b076d99fa5fa17https://doi.org/10.3389/fimmu.2025.1624011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Effects of COVID-19 in Hospitalized and Non-Hospitalized Pediatric Patients: A Prospective Study2025
  2. 2Long-term effects of SARS-CoV-2 infection in hospitalized children: findings from an Italian single-center study2024 · 11 citations
  3. 3Long COVID in Children and Adolescents: Mechanisms, Symptoms, and Long-Term Impact on Health—A Comprehensive Review2025 · 43 citations
  4. 4Impact of Long COVID on Lung Function in Children2024 · 6 citations
  5. 5Phenotyping Pediatric Long COVID: Symptom Clusters from a Longitudinal Multicenter Italian Cohort2026