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September 17, 2025Frontiers in Medical TechnologyOpen Access

Optimization of bacteriocin production by Lactobacillus rhamnosus CW40: exploring its therapeutic and antibacterial scope

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Authors

PUPreeti UpadhyayGovt. Dental College & HospitalAVAbhishek VermaIndian Council of Forestry Research and EducationHJHarshada JoshiMohanlal Sukhadia University

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Overview

This study demonstrates enhanced bacteriocin yield at optimal conditions in Lactobacillus rhamnosus, suggesting potential as natural food preservatives and therapeutic agents.

Key Points

  • Maximum bacteriocin production of 4,098 AU/mL against E. coli highlights its therapeutic potential.
  • Lactobacillus rhamnosus CW40 showed antimicrobial properties against Bacillus subtilis, Bacillus cereus, and E. coli.
  • Gel filtration chromatography was used to purify the bacteriocin, confirming its proteinaceous nature.
  • The strain exhibited broad antibiotic resistance and tolerated up to 0.3% ox gall, indicating robustness.

Cite This Study

Upadhyay et al. (2025) studied this question.

synapsesocial.com/papers/68d4605131b076d99fa5fa31https://doi.org/10.3389/fmedt.2025.1663924
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