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September 17, 2025Journal of Case Reports and Images in OncologyOpen Access

Apocrine adenocarcinoma in a patient with a partner and localizer of BRCA2 (PALB2) genetic mutation: A case report

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Authors

ABAnna BrelandTCTerrance Cooper

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Overview

Case report details apocrine adenocarcinoma diagnosis in a patient with the PALB2 mutation, suggesting unique implications.

Key Points

  • Diagnosis confirmed apocrine adenocarcinoma in a 72-year-old male with no previous breast abnormalities, following imaging.
  • Shave biopsy results indicated estrogen receptor negative, progesterone receptor negative, and HER2 positive diagnostics.
  • Treatment included local excision and a neoadjuvant chemotherapy regimen of carboplatin and paclitaxel.
  • Findings emphasize the rarity of apocrine adenocarcinoma, particularly in patients with a PALB2 genetic mutation.

Cite This Study

Breland et al. (2025) studied this question.

synapsesocial.com/papers/68d4605131b076d99fa5fb8fhttps://doi.org/10.5348/100149z10ab2025cr
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Apocrine Carcinoma of the Breast: A Case Report and Review of the Literature2025
  2. 2Accessory Breast Apocrine Carcinoma: Report of a Rare Case2026
  3. 3Primary Cutaneous Apocrine Carcinoma: Diagnostic and Management Difficulties of an Uncommon Neoplasm2024
  4. 4Case Report: A challenging diagnosis of an apocrine sweat gland carcinoma2024
  5. 5Metastatic Cutaneous Apocrine Carcinoma: Diagnostic and Therapeutic Challenges in a Rare Malignancy2026