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July 24, 2026CureusOpen Access

Metastatic Cutaneous Apocrine Carcinoma: Diagnostic and Therapeutic Challenges in a Rare Malignancy

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Authors

BCB. ChanCIChika IguhAHAndrew Hwang

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Overview

Case report highlights challenges in treating hormone receptor-positive metastatic cutaneous apocrine carcinoma, suggesting potential for combined therapies.

Key Points

  • Examine the diagnostic and therapeutic challenges in managing metastatic cutaneous apocrine carcinoma.
  • Detailed case analysis of a 50-year-old male with metastatic cutaneous apocrine carcinoma.
  • Molecular profiling and immunohistochemical analysis performed to identify key mutations and receptor expressions.
  • Sequential therapy with endocrine treatment and chemotherapy documented over the patient's clinical course.
  • Patient exhibited KMT2C mutation and demonstrated overexpression of multiple cancer-related pathways.
  • Progressed through multiple treatment lines including tamoxifen and pembrolizumab with associated complications.
  • Therapeutic approaches led to meaningful disease control despite challenging clinical management.

Cite This Study

Chan et al. (2026) studied this question.

synapsesocial.com/papers/6a630020395161722cd1536bhttps://doi.org/10.7759/cureus.113113
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