Virtual screening identifies multi-target xanthine oxidase inhibitors from herbal medicines for hyperuricemia treatment, suggesting promising candidates.
Hyperuricemia is an increasingly serious metabolic disease. However, xanthine oxidase inhibitors (XOIs) can fundamentally solve the problem of uric acid overproduction. In this paper, through virtual screening and network pharmacology, 73 potential compounds are discovered from six Chinese herbal medicines containing phenylpropanoids. These compounds treat hyperuricemia through crucial targets XDH, IL6, TLR4, HIF1A, HSP90AA1 and MMP2 synergistic effect. Further assay activities of inhibitory xanthine oxidase and antioxidant discover that taxifolin, morin and ellagic acid are deserved further study as the most promising anti-hyperuricemia multi-target XOIs candidates. Therefore, this study provides certain theoretical foundation for exploring effective treatment of hyperuricemia.
No takes yet. Share an insight, caveat, or question.
Hu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: