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September 17, 2025Critical Reviews in Toxicology

Evaluating health impacts of exposure to PFAS mixtures: a systematic review of epidemiological studies using mixture methods

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Authors

MKM. KempKTKrishanth ThoppeKJKent W. Jones

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Overview

Systematic review evaluates health effects of PFAS mixtures, finding associations with cholesterol levels and hypertension.

Key Points

  • An association exists between exposure to PFAS mixtures and hypertension, showing significant health implications in the population.
  • The review identified 233 cohort studies and 39 case-control studies among other methodologies, showcasing diverse health outcomes tested.
  • Using mixture methods, the systematic review enhanced the understanding of health risks linked to PFAS exposure beyond individual substances.
  • Findings indicate strong links to adiposity and cholesterol levels, while other health impacts are still considered suggestive or limited.

Cite This Study

Kemp et al. (2025) studied this question.

synapsesocial.com/papers/68d4605931b076d99fa5ff50https://doi.org/10.1080/10408444.2025.2546427
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