Extending the General Kinetic Model for Perfusion to Time-Spatial Labeling Inversion Pulse (Time-SLIP) Applications

Motivation: Extending the General Kinetic Model (GKM) to Time-Spatial Labeling Inversion Pulse (Time-SLIP) cerebrospinal fluid (CSF). Goal(s): The goal is to extend the GKM to support Time-SLIP CSF acquisitions, improving perfusion measurement accuracy and fluid dynamic visualization. Approach: The study used numerical simulations and phantom experiments on a 3T MRI scanner to validate the extended GKM for both dark and bright Time-SLIP methods. Results: The extended GKM successfully quantified perfusion for dark and bright Time-SLIP, with less than 5% variation in perfusion coefficients across multiple configurations. The dark method yielded stronger perfusion signals, while the bright method provided superior visualization of fluid dynamics. Impact: The extension of GKM to Time-SLIP improves perfusion quantification and visualization of fluid dynamics, providing a more precise tool for studying conditions involving cerebrospinal fluid (CSF) movement. This opens possibilities for more complex fluid dynamic investigations.