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September 1, 2025Obstetrical & Gynecological Survey

Atosiban Versus Placebo for Threatened Preterm Birth (APOSTEL 8): A Multicentre, Randomized Controlled Trial

Larissa I. van der Windt Job Klumper Ruben G. Duijnhoven Marjolein Kok Carrie Ris‐Stalpers Marjon A. de Boer Anton H. van Kaam Eva Pajkrt Ben W. Mol Kate F. Walker Fionnuala M. McAuliffe Joris van der Post Carolien Roos Martijn A. Oudijk

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Key Points

Atosiban demonstrates effectiveness compared to placebo in managing threatened preterm birth.
A significant outcome of improved pregnancy prolongation was observed over 48 hours in treated participants.
The study uses a multicentre, randomized controlled trial design to assess safety and efficacy.
These findings highlight a promising approach to managing pregnancies at risk of premature delivery.

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Implication

Randomized controlled trial compares atosiban and placebo for threatened preterm birth, indicating potential benefits of tocolytic treatment.

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Cite This Study

Windt et al. (2025) studied this question.

synapsesocial.com/papers/68d4605931b076d99fa600ff https://doi.org/10.1097/01.ogx.0001168076.04561.90

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Atosiban Versus Placebo for Threatened Preterm Birth (APOSTEL 8): A Multicentre, Randomised Controlled TrialRCT · 2026
2Atosiban versus placebo in the treatment of threatened preterm birth between 30 and 34 weeks gestation: study protocol of the 4-year APOSTEL 8 follow-up2024
3Atosiban and Managing Women in Preterm LabourMeta-Analysis · 2026
4Comparison of Tocolytic Treatment Protocols in Threatened Preterm Labor: A Prospective Observational StudyCohort Study · 2026
5Study on Safety and Efficacy of Atosiban and Nifedipine in the Management of Threatened Preterm Labour2024