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September 17, 2025CureusOpen Access

Rapid Enlargement of Squamous Cell Carcinoma Arising From Hidradenitis Suppurativa During Bimekizumab Therapy

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Case report reveals rapid squamous cell carcinoma development in hidradenitis suppurativa during treatment, suggesting careful monitoring.

Rapid enlargement of squamous cell carcinoma occurred after initiating bimekizumab for hidradenitis suppurativa.
The tumor expanded to 15 cm within four months, leading to excision and confirming high-grade invasive squamous cell carcinoma.
Biologic therapy, specifically interleukin-17 inhibitors, requires vigilance due to potential cancer risk in hidradenitis suppurativa patients.
Early biopsy of progressively non-healing lesions may be critical to exclude malignancy in similar patients.

Yamamura et al. (2025) studied this question.

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Case report reveals rapid squamous cell carcinoma development in hidradenitis suppurativa during treatment, suggesting careful monitoring.