What question did this study set out to answer?

To investigate the role of interleukin-17 in de novo carcinogen-induced skin cancer and its impact on the inflammatory tumor microenvironment.

December 14, 2010Cancer ResearchOpen Access

IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

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Authors

LWLin WangCornell University TYTangsheng YiHoward Hughes Medical Institute WZWang ZhangThird People's Hospital of Hefei

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Implication

Preclinical study reveals that IL-17 deficiency dramatically reduces skin tumor development in mice, indicating the IL-17-Stat3 pathway promotes cancer-associated inflammation.

Key Points

To investigate the role of interleukin-17 in de novo carcinogen-induced skin cancer and its impact on the inflammatory tumor microenvironment.
Utilized wild-type and IL-17 knockout mice subjected to a two-stage DMBA/TPA chemical skin carcinogenesis protocol.
Assessed tumor incidence, Stat3 pathway signaling activation, epidermal cell proliferation, hyperplasia, chemokine expression, and myeloid cell infiltration.
Disruption of IL-17 dramatically reduced skin tumor development and was accompanied by diminished Stat3 activation.
IL-17 deficiency decreased proliferative and antiapoptotic gene expression, epidermal cell proliferation, and hyperplasia.
Loss of IL-17 was associated with reduced expression of Stat3-regulated chemokines and decreased infiltration of myeloid cells into the tumor microenvironment.

Cite This Study

Wang et al. (2010) studied this question.

synapsesocial.com/papers/69d892c67392c8ce61beeeaf https://doi.org/10.1158/0008-5472.can-10-0775

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Implication

Preclinical study reveals that IL-17 deficiency dramatically reduces skin tumor development in mice, indicating the IL-17-Stat3 pathway promotes cancer-associated inflammation.

IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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