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Multimodal neuroimaging related to cerebrospinal fluid biomarkers and cognitive function in Alzheimer's disease

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Lateral temporal and occipital gray matter volumes positively correlated with cognitive function (MMSE scores).
White matter hyperintensities were negatively associated with amyloid-β levels, impacting cognitive performance.
Cerebral blood flow in the lateral temporal region showed a significant relationship with cognitive function scores.
Structural equation modeling indicated links between reduced amyloid levels, increased white matter hyperintensities, and impaired cognition.

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Exploration of CSF biomarkers and neuroimaging features reveals implications for cognitive function in Alzheimer's disease.

Kitayama et al. (2025) studied this question.

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