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This is a Quantitative Study study.

September 18, 2025Open Access

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

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Authors

EQEstefanía Quesada‐MasachsUniversity of Miami SZSamuel ZilbermanLa Jolla Institute for Immunology TCTiffany ChuCreighton University

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Implication

Analysis reveals increased macrophage infiltration in type 1 diabetes patients and autoantibody positive donors, suggesting their role in disease progression.

Key Points

Macrophage infiltration was notably highest in pancreata from type 1 diabetes donors, indicating their involvement in the disease.
Higher densities of macrophages were seen in islet regions of autoantibody positive donors compared to non-diabetic individuals.
The expression of HLA class II was significantly upregulated near islets in type 1 diabetes patients, correlating with stressed beta cells.
These findings suggest that macrophages could be crucial in the initiation and progression of type 1 diabetes.

Cite This Study

Quesada‐Masachs et al. (2025) studied this question.

synapsesocial.com/papers/68d461b631b076d99fa60913 https://doi.org/10.1101/2025.09.13.676053

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Implication

Analysis reveals increased macrophage infiltration in type 1 diabetes patients and autoantibody positive donors, suggesting their role in disease progression.

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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