Analysis reveals that TSPO deficiency alters lipid mobilization and affects adipocyte function, indicating a new role for porphyrins in metabolic regulation.
Key Points
Tspo deficiency results in increased white adipose tissue mass and adipocyte hypertrophy under a high-fat diet.
Key lipolytic genes are suppressed in Tspo knockout mice, leading to reduced circulating non-esterified fatty acids.
Lipidomic profiling shows impaired lipid mobilization rather than changes in lipid composition in Tspo -/- mice.
Protoporphyrin IX directly influences adipocyte lipid metabolism, highlighting its potential role in obesity therapies.