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This is a Cross-Sectional Study study.

The influence of biological sex on the metabolic basis of skeletal muscle fatigue in vivo

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Study evaluates muscle fatigue's relationship with metabolites in men and women, suggesting similar metabolic bases.

The decline in muscle contractile function during high-intensity exercise is generally less pronounced in women than in men.
In both sexes, muscle fatigue shows a stronger relationship with inorganic phosphate accumulation than with hydrogen ions.
The decline in contractile function for a given increase in intramuscular metabolites is similar between men and women.
The results indicate that metabolic disturbances, rather than intrinsic resistance to metabolites, underpin exercise-induced fatigue.

Laginestra et al. (2025) studied this question.

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