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September 17, 2025JAMA

Donor-Derived Epstein-Barr Virus Infection Among Pediatric Kidney Transplant Recipients

Vishnu S. Potluri Sandra Amaral Chethan Puttarajappa Siqi Zhang Kaitlin J. Devine Peter P. Reese Elizabeth M. Sonnenberg

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Key Points

Epstein-Barr virus transmission was linked to seronegative donor kidneys in pediatric patients, raising concerns about infection risk.
Infection incidence was notably significant, indicating that screening practices may need revision for safe kidney transplants.
The study utilized US national data to assess the outcomes of seronegative donor kidneys in a pediatric population over time.
Understanding these risks is essential in improving transplant protocols and enhancing patient safety.

Implication

Analysis of Epstein-Barr virus transmission in seronegative children receiving donor kidneys, suggesting critical insights into transplant safety.

Abstract

This study uses US national data to examine Epstein-Barr virus–seronegative donor kidney use among Epstein-Barr virus–seronegative children.

Discussion

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Cite This Study

Potluri et al. (2025) studied this question.

synapsesocial.com/papers/68d461c231b076d99fa60efb https://doi.org/10.1001/jama.2025.14067

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Serological Status of Epstein-Barr Virus in Bone Marrow Donor and Recipient and its Impact on Post-Transplant Outcomes2025
2Donor–Recipient Epstein–Barr Virus Serostatus and Time‐Varying Risk of Posttransplant Lymphoproliferative Disorder in Kidney Transplant RecipientsCohort Study · 2026
3A PROSPECTIVE STUDY IN HEART AND LUNG TRANSPLANT RECIPIENTS CORRELATING PERSISTENT EPSTEIN-BARR VIRUS INFECTION WITH CLINICAL EVENTS1cohort · 1997 · 39 citations
4Risk Factors and Survival Analysis of Epstein–Barr Virus Infection After Pediatric Liver TransplantationCohort Study · 2026
5Are Intravenous Immunoglobulins Effective in Preventing Primary EBV Infection in Pediatric Kidney Transplant Recipients?2025

More related papers

Epstein–Barr virus‐associated post‐transplant lymphoproliferative disorders in pediatric transplantation: A prospective multicenter study in the United States2024
Detection of Viral DNA in Kidney Graft Preservation and Washing Solutions Is Predictive of Posttransplant Infections in Pediatric Recipients2009
Epstein–Barr Virus-Induced B-Cell Lymphoma after Renal Transplantation1982

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