Why the study?
How does post-transplant immunosuppression affect Epstein-Barr virus (EBV) infection and specific immunity in cardiothoracic transplant recipients?
Population
30 cardiothoracic (heart and lung) transplant recipients
Comparison
Post-transplant immunosuppression and acyclovir… vs Pretransplant baseline and healthy controls
Design
Cohort
Follow-up
2 years
Authors
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Post-transplant CTL suppression associates with higher EBV load in cardiothoracic recipients; hypothesis-generating for monitoring strategies, does not yet change practice.
How does post-transplant immunosuppression affect Epstein-Barr virus (EBV) infection and specific immunity in cardiothoracic transplant recipients?
Post-transplant immunosuppression significantly decreases EBV-specific host immune function, leading to increased EBV viral load and shedding in cardiothoracic transplant recipients.
Haque et al. (1997) studied this question.
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