Green Synthesis of Cefixime@Hematite as Multifunctional Biological Agent

The excessive use of antibiotics has contributed to multidrug resistance, the need for higher doses, increased healthcare costs and a greater risk of side effects raising concerns about the end of an antibiotic era. In this study, we aimed to overcome the limitations associated with cefixime antibiotic by stabilizing it with hematite nanostructures. These nanostructures were fabricated using a green approach and employed as carriers to support cefixime. Spectroscopic and microscopic analysis confirmed the successful fabrication of hematite nanostructures and incorporation of cefixime. The hemolysis measurement verified the biocompatibility of hematite encapsulated cefixime. Biological evaluation of cefixime infused nanostructures demonstrated superior kinase inhibition, antifungal and antioxidant potency relative to its unmodified form. Moreover, cytotoxicity measurement through brine shrimp lethality assay (BSLA) showed pronounced effect. These outcomes illustrate the capacity of currently fabricated biocompatible cefixime infused hematite as a promising nanostructures formulation for various bio‐medical applications.