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September 18, 2025

Genetic Susceptibility and Childhood Adversity: Gene-Environment Interaction in Attention-Deficit/Hyperactivity Disorder

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Authors

MAMaría Soler ArtigasNLNatalia LlongaJCJudit Cabana‐Domínguez

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Overview

Case-only design identifies how childhood adversity amplifies genetic effects in ADHD, suggesting implications for treatment.

Key Points

  • Significant interactions were found between genetic liability and childhood adversity in ADHD individuals.
  • The effect of genetic susceptibility on ADHD was 1.31 times stronger in those with emotional abuse or family stress.
  • Considering gene-environment interactions can help explain the variability seen in ADHD symptoms and severity.
  • The study utilized a case-only design with 852 adults diagnosed with ADHD to explore these interactions.

Cite This Study

Artigas et al. (2025) studied this question.

synapsesocial.com/papers/68d461cb31b076d99fa610e5https://doi.org/10.21203/rs.3.rs-7427552/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Individual Differences in The Intergenerational Transmission of Attention-Deficit/Hyperactivity Disorder: The Role of Genetic and Environmental Factors2025
  2. 2The Loop That Builds Itself Polygenic Risk, Compensatory Family Norms, and Intergenerational Transmission of ADHD-Related Phenotypes2026
  3. 3Shared genetic background between children and adults with attention deficit/hyperactivity disorder2019 · 19 citations
  4. 4Integrating genetics, neuroimaging, and environment in ADHD: a systematic umbrella review of meta-analytic evidence2026
  5. 5Shared genetic background between children and adults with attention deficit/hyperactivity disorder2020 · 111 citations