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September 18, 2025International Journal of Molecular SciencesOpen Access

The Biological Function of Genome Organization

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Authors

XYXin YangBGI Group (China)HZHongni ZhuChinese Academy of SciencesYLYajie LiuAnhui Medical University

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Overview

This review synthesizes insights into how genome architecture affects transcription and disease processes.

Key Points

  • Three-dimensional genome organization modulates transcription and gene co-expression.
  • Structural disruptions in genome organization are linked to various human diseases.
  • Architectural proteins and non-coding RNAs dynamically establish genomic structures in cells.
  • Understanding genome organization is essential for revealing disease mechanisms and potential therapies.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68d461cb31b076d99fa61137https://doi.org/10.3390/ijms26189058
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