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September 18, 2025Chinese Medical JournalOpen Access

Long-term outcomes of CNCT19 chimeric antigen receptor T-cell therapy in relapsed or refractory aggressive B-cell lymphoma

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Authors

WLWei LiuArmy Medical UniversityTXTing XieShandong University of Traditional Chinese MedicineZZZhuoxin ZhangChinese Academy of Medical Sciences & Peking Union Medical College

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Implication

Pilot clinical trial shows safety and efficacy of CNCT19 in relapsed B-cell lymphoma, indicating potential for treatment.

Key Points

  • The estimated 5-year overall survival rate for patients was 37.5%, highlighting CNCT19's effectiveness.
  • The study identified cytokine release syndrome occurring in 68.8% of patients, primarily graded as mild.
  • Patients had a median of 3 prior therapy lines, underlining the challenge of managing relapsed or refractory B-cell lymphoma.
  • After 54 months of follow-up, the study suggests that CNCT19 may offer prolonged survival benefits for aggressive B-cell lymphoma patients.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d461cb31b076d99fa611b9https://doi.org/10.1097/cm9.0000000000003716
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