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January 1, 2025RSC Chemical BiologyOpen Access

A trifunctional probe for generation of fluorogenic glycan-photocrosslinker conjugates.

Brandon Vreulz Daphnée De Crozals Samy Cecioni

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Key Points

The approach enhances binding affinity of glycans to lectins, crucial for studying biological processes involving glycans.
A fluorogenic probe was created to improve detection of glycan-lectin interactions, facilitating their study.
This method employs photoaffinity labeling, effectively capturing transient binding events in biological systems.
The findings can lead to advancements in glycan research, including potential applications in therapeutic fields.

Implication

A trifunctional probe generates fluorogenic glycan-photocrosslinker conjugates, suggesting improved binding affinity in glycan-lectin interactions.

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Cite This Study

Vreulz et al. (2025) studied this question.

synapsesocial.com/papers/68d461cb31b076d99fa61308 https://doi.org/10.1039/d5cb00206k

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