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September 18, 2025Journal of NeuroscienceOpen Access

Switching patterns of cortical-subcortical interaction in the human brain

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Cortical-subcortical interactions shape whole-brain spontaneous activity, indicating a dual role of subcortex in functional connectivity patterns.
Functional connectivity shifts between cortex and subcortex are synchronized, revealing complex interaction dynamics during spontaneous brain activity.
Analysis using Human Connectome Project data identifies two core subcortical clusters influencing cortical regions with distinct coupling patterns.
Limbic regions show flexible coupling with different cortical networks, emphasizing the need to include subcortical structures in brain studies.

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Dynamic functional connectivity analysis reveals synchronized shifts in cortical and subcortical interactions, highlighting their significance.

Nazzi et al. (2025) studied this question.

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Dynamic functional connectivity analysis reveals synchronized shifts in cortical and subcortical interactions, highlighting their significance.