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Experimental analysis reveals hyperhomocysteinemia impacts mitochondrial function in rat hearts, suggesting carnitine chloride may mitigate these effects.
The article is devoted to the issue of the influence of hyperhomocysteinemia on the indices of mito-chondrial functioning in rat hearts. Mild experimental hyperhomocysteinemia associated with the load of D, L-homocysteine thiolactone is accompanied by an increase in the activity of succinate dehydrogenase and a decrease in the intensity of oxidative modification of proteins. The use of ex-ogenous carnitine chloride prevents changes in the activity of mitochondrial enzymes and main-tains the level of oxidative processes in cardiomyocytes under conditions of experimental hyperho-mocysteinemia.
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Uryasev et al. (2025) studied this question.
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