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July 30, 2001Journal of Cellular Biochemistry

Induction of oxidative stress by homocyst(e)ine impairs endothelial function*

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Population

Isolated aortas from normotensive Wistar rats and cultured endothelial cells

Comparison

Homocysteine in culture medium for 14 days, with… vs Untreated control aortas

Design

Preclinical

Follow-up

14 days

Authors

VMVibhas S. MujumdarState Street (United States)GAGiorgio M. AruJackson Memorial HospitalSTSuresh C. TyagiMount Sinai Beth Israel

Discussion

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Implication

Animal data suggest nicotinamide merits human investigation for homocysteine-related endothelial dysfunction; leaves open clinical translation.

Structured PICO

P
Population
Isolated aortas from normotensive Wistar rats and cultured endothelial cells
I
Intervention
Homocysteine in culture medium for 14 days, with or without co-incubation of nicotinamide, tissue inhibitor of metalloproteinase-4 (TIMP-4), or caspase inhibitor YVAD-CHO
C
Comparator
Untreated control aortas
O
Outcome
Endothelial-dependent vasodilatation and medial hypertrophic thickeningsurrogate

Homocysteine induces oxidative stress, leading to endothelial dysfunction, MMP activation, and vascular hypertrophy, which can be mitigated by antioxidants and MMP/caspase inhibitors.

Cite This Study

Mujumdar et al. (2001) studied this question.

synapsesocial.com/papers/6a72090f31a3df824329ed43https://doi.org/10.1002/jcb.1175
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.1976 · 935 citations
  2. 2THE REASON FOR THE SHAPE OF THE DISTENSIBILITY CURVES OF ARTERIES1957 · 293 citations
  3. 3Comparison between endocardial and great vessel endothelial cells: morphology, growth, and prostaglandin release1995 · 50 citations
  4. 4Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase1997 · 673 citations