A Case Of Risperidone– Induced Angioedema: Bad “RISP” Onse

Background: Risperidone is a second-generation antipsychotic widely used for schizophrenia and schizoaffective disorder. Although generally well tolerated, rare but potentially serious adverse effects such as angioedema have been reported. Case presentation: We describe a 38-year-old male with paranoid schizophrenia who developed acute angioedema on day 9 of risperidone therapy. Laboratory evaluation excluded complement-mediated and hereditary etiologies. Risperidone was discontinued, cross-tapered to aripiprazole, and the patient received systemic corticosteroids and antihistamines, resulting in complete resolution within four days. Conclusion: Clinicians should be aware of risperidone-induced angioedema, monitor inflammatory markers to aid diagnosis, and promptly discontinue the offending agent to prevent complications.