Network meta-analysis shows growth hormone and testosterone enhance height gain in children with idiopathic short stature, implying potential treatment options.
Background Idiopathic short stature (ISS) is defined as height more than two standard deviations below the mean for age and sex, without an identifiable pathological cause. Pharmacologic options such as growth hormone (GH), testosterone, and aromatase inhibitors (AIs) have been studied for their potential to promote height gain in affected children and adolescents.
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Zhang et al. (2025) studied this question.
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