Asymmetric dearomatization reaction achieves good enantioselectivity in spirocyclic products, indicating potential in synthetic applications.
We report an asymmetric dearomatization reaction of enyne-tethered biaryls through Pd(0)/chiral phosphoric acid cocatalyzed intramolecular hydrofunctionalization, furnishing spirocyclic hexenones and indolenines with fair to excellent enantioselectivity. A Pd(0) π-Lewis base-promoted protonation may be involved, and chiral phosphate anion plays a key role in enantiocontrol.
No takes yet. Share an insight, caveat, or question.
Pi et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: