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This is a Experimental Study study.

Late-Stage Tryptophan Modification of Native Peptides through Photochemical Indole-to-Quinazoline Editing

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This study demonstrates a novel tryptophan-specific modification method for peptides, highlighting its broad application potential.

The new method allows for effective tryptophan modification in various peptide types, including linear and cyclic.
The technique was successfully applied to modify commercially available peptide drugs, expanding its utility.
Mechanistic insights include oxidative indole cleavage interruption through ammonia, suggesting an innovative pathway.
This research underscores the potential for new peptide modification strategies to generate bioactive analogues efficiently.

Li et al. (2025) studied this question.

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